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Mock fasting and cancer therapy – this is how science describes an approach that is increasingly being investigated in clinical studies. Fmd during chemotherapy, fasting mimicking diet chemotherapy, eating less during chemotherapy, valter longo fmd research and cancer cells healthy cells difference form the scientific basis for a question that sounds surprising: Can eating less during chemotherapy be useful?

fmd krebstherapie unterstuetzung is based on a biological difference: healthy cells can switch to a protective mode with little food – cancer cells cannot. Calorie chemotherapy cancer research is investigating precisely this mechanism.

The valter longo sham fasting study represents 30 years of research that shows The cell reaction nutrient deficiency cancer could be therapeutically useful. Fmd cancer therapy support is currently being tested in several clinical studies worldwide.

Sham fasting and cancer therapy: what's behind it?

An easy-to-understand overview of the Fasting Mimicking Diet

Eating less during chemotherapy - can it make sense?

The Fasting Mimicking Diet (FMD) is currently being investigated in studies as a possible support during cancer therapies. The approach sounds surprising at first: eating less during chemotherapy, even though doctors normally advise you to consume enough calories. However, there is scientific reasoning behind this idea.

Research is investigating whether healthy cells and cancer cells react differently to a lack of nutrients. Healthy cells can switch to a “protective mode” when there is little food and protect themselves from harmful influences. Cancer cells, on the other hand, have lost this ability – they continue to grow regardless of whether food is available or not. It is precisely this difference that researchers are trying to exploit.

The FMD is based on 30 years of research by Prof. Valter Longo, who originally studied healthy ageing. In the process, he discovered mechanisms that could also be of interest for cancer research.

cancer diagnostics

FMD during chemotherapy – A surprising approach

Fasting mimicking diet chemotherapy sounds counterintuitive at first glance: why should someone eat less during chemotherapy? However, fmd krebstherapie unterstuetzung is based on a clear biological principle. Research on fasting mimicking diet chemotherapy shows that food deprivation affects healthy and diseased cells in fundamentally different ways.

Eating less during chemotherapy – The biological logic

Eating less during chemotherapy can put healthy cells into a protective mode that makes them more resistant. Calorie chemotherapy cancer research shows that cancer cells do not have this ability to adapt. Calorie reduction during chemotherapy could therefore mean a selective advantage for the patient.

Valter Longo FMD Research – 30 years of science

Valter longo fmd research originally began with the question of healthy ageing. The valter longo sham fasting study revealed mechanisms that could also be relevant for cancer therapy. Today, clinical studies worldwide are investigating valter longo fmd research as a possible supplement to standard therapy.

Cancer cells Healthy cells Difference – The core of the approach

The difference between cancer cells and healthy cells is the scientific core of FMD research. The cell response to nutrient deficiency shows cancer: Healthy cells downregulate their metabolism when deprived of food – cancer cells continue to grow. The aim of current research is to utilize this cancer cell healthy cell difference therapeutically.

The podcast: Science explained in an understandable way

Can nutrition support cancer therapies?

In this detailed podcast, you will learn how the mock fasting diet works and what current research results show. The podcast explains the biological principles in an understandable way: Why do healthy cells and cancer cells react differently to a lack of food? What role does the so-called IGF-1 signaling pathway play in this?

You will also hear about a remarkable population group in Ecuador whose metabolism has provided researchers with important clues and learn about study results – both from animal experiments and from initial clinical studies with cancer patients.

NOTE: The content of this podcast was created with notebooklm.google.com and represents scientific research results and is not a therapy recommendation. Any use during cancer therapy requires medical supervision and individual clarification.

Your way to information

The podcast guides you step by step through these complex scientific contexts and makes the research background understandable.

Talk to your doctor: If you are interested in current research approaches, discuss this information with your oncologist or a specialized center.

Realistic expectations: Ferroptosis is an active field of research. The mechanisms described are mainly based on laboratory studies and preclinical investigations. Medical decisions should be based on sound medical information and individual advice.

Important note: The podcast is intended solely to provide information about scientific research approaches. It does not constitute medical advice and does not replace a consultation with your doctor.

FREQUENTLY ASKED QUESTIONS ABOUT THE SHAM FASTING DIET

Why is this diet being studied at all?

What is the difference between normal fasting and the sham fasting diet?

The FMD is not a complete fast with only water. It is a precisely compiled 5-day program with a greatly reduced calorie intake. On the first day about 1,100 calories are consumed, on days 2 to 5 only 700-800 calories - mainly from vegetables, healthy fats and complex carbohydrates, but with very little protein. The aim is to trigger the biological effects of fasting without patients having to completely abstain from food.

How should healthy cells be protected?

Studies show that healthy cells shut down their activity when there is a lack of nutrients and switch to a kind of "repair and protection mode". In the podcast, this is compared to people barricading themselves in their house before a storm. Cancer cells, on the other hand, cannot activate this mechanism - they remain vulnerable even when there is little food available.

What study results are available on the combination with chemotherapy?

A study with breast cancer patients investigated whether FMD in addition to standard chemotherapy can influence the response to treatment. Patients who underwent FMD were more likely to experience a significant reduction in tumor cells (90-100%) after treatment. Survival times were also examined: On average, longer survival times were observed in the group with FMD than in the group with chemotherapy alone. These data originate from initial clinical studies and are currently being investigated further.

For whom would this diet not be suitable?

The FMD is not suitable for everyone. Studies have excluded people who are severely underweight (BMI under 18), pregnant women, people with severe heart or kidney disease and people with a history of eating disorders. Diabetes requires particularly close medical monitoring, as the need for medication can change quickly.

Does FMD replace standard cancer therapy?

No. In all research work, FMD is being investigated as a possible addition to established therapies - not as a replacement. Especially in the early stages of the disease, where chemotherapy or surgery offer good chances of recovery, it is essential that these therapies are carried out. FMD is being investigated to see whether it can influence the effectiveness of standard therapies and reduce their side effects.

Find out more in the podcast:

Further questions such as "What does healthy ageing have to do with cancer?", "What role does the IGF-1 signaling pathway play?", "When exactly would the FMD be performed?" and many more details on the scientific background are answered in detail in the full podcast.

Research for individualized approaches

The scientific vision – to better understand cancer through innovative diagnostics and individualized concepts – is increasingly supported by research approaches such as the investigation of metabolic interventions. Whether FMD will play a role in clinical practice in the future depends on further study results.

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Was ist die Testung genetischer Expressionswerte von Krebszellen?

Durch molekularbiologische Analyse identifizieren wir das individuelle Aktionsprofil eines Tumors und finden die therapeutischen Angriffspunkte.

Die Messung der RNA-Genexpressionswerte ist dem Tumorgeschehen näher als eine reine Mutationsanalyse. Mit dieser Messung kann man für wichtige Signalwege des Tumors das konkrete und aktuelle Aktionsprofil und deren Eigenschaften ermitteln.

Per Flüssigbiopsie ist eine Gewinnung frischer lebender Tumorzellen einfach und schmerzfrei möglich.  

Es werden auch Tumorzellen aus Körperregionen gewonnen, die wie in Lunge, Bauchspeicheldrüsen oder Gehirn für herkömmliche Gewebebiopsien oft nur schwierig zu erreichen sind.

Man kann weiterhin auch Tumorzellen aus Urin, Aszites oder Liquor erhalten.

Wenn Gewebebiopsate vorliegen, kann man auch diese nutzen. Somit sind vielfältige Möglichkeiten gegeben, um Tumorzellen zu gewinnen.

Die iSelect und iComplete Tests liefern entscheidende Erkenntnisse bezüglich:

• der Aggressivität des Tumors

• der Manipulation des Immunsystems durch den Tumor

• der Resistenzen gegenüber Medikamenten

• der Aktivität relevanter Signale

• der Wirksamkeit bestimmter Substanzen

Die Messergebnisse werden therapeutischen Substanzen zugeordnet, basierend auf anerkannten Studien, sodass der behandelnde Arzt Optionen für eine gezielte Therapie erhält.

Üblicherweise werden die Tumorzellen aus einer Blutprobe extrahiert, gefolgt von der Analyse der RNA, um die Aktivität von Genen zu bestimmen. Die Tumorzellen können aber auch aus einer Biopsie, Liquor oder Aszites entnommen werden.

Die mit dem iSelect oder iComplete Test gewonnen Therapieoptionen zeigen personalisierte und für den individuellen Tumor zielgerichtete Therapieoptionen auf, die der Therapeut umsetzen kann. Weiterhin werden auch individuell für den vorliegenden Tumor ungeeignete Substanzen die z.B. in der Chemotherapie eingesetzt werden, aufgezeigt. Damit kann man z.B. stark toxische Therapeutika, die der Tumor einfach durchschleust, identifizieren und für die Therapie ausschließen.

Bitte sprechen Sie uns über die kostenlose Beratung an, damit wir den richtigen Test herausfinden und Ihnen die damit verbundenen Kosten mitteilen können.

Die Laborarbeit dauert ca. 10 Arbeitstage. Danach wird ein Bericht geschrieben, der je nach Komplexität des Falles ca. 1 – 3 Arbeitstage dauern kann. Der Bericht muss wegen gesetzlicher Vorgaben im Falle von Krebs an den behandelnden Arzt gehen. Er kann dann den Bericht an den Patienten weiterleiten.

Die Zuverlässigkeit hängt von verschiedenen Faktoren ab, einschließlich der Testmethode und der Qualität der genommenen Probe. In vielen Fällen sind Liquid Biopsy-Tests jedoch eine zuverlässige Ergänzung zu anderen Diagnosemethoden.

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Rufen Sie bei uns an oder schicken Sie uns eine Nachricht. Wir beraten Sie zu unseren Tests. Das entsprechende Blutentnahmeset lassen wir Ihrem Arzt kostenlos zukommen.

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Die Blutabnahme erfolgt bei dem Arzt Ihres Vertrauens oder einem Arzt unseres Netzwerkes. Wichtig für Chemotherapie-Patienten: Planen Sie diesen Termin frühestens 10-14 Tage nach Ihrer letzten Chemotherapie.

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Teilen Sie uns spätestens einen Tag vor der geplanten Blutabnahme per E-Mail oder telefonisch mit, wann und wo die Probe abgeholt werden soll. Wir benötigen Ort, Datum und ein Zeitfenster von 2 Stunden für unseren Kurierdienst.

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Bringen Sie das von uns erhaltene Blutabnahmeset zu Ihrem Arzttermin mit. Nach der Blutabnahme wird die Probe durch unseren Kurierdienst abgeholt und zu unserem Labor transportiert.

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  • Prüfen Sie die Vollständigkeit der beiliegenden Unterlagen
  • Lassen Sie den Arzt den Auftrag zur molekularen Diagnostik mit Ihrer Einwilligung und Unterschrift ausfüllen
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  • Senden Sie alle Formulare unterschrieben im Original an uns zurück

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Die Berichterstellung erfolgt nach Zahlungseingang des Patienten je nach Fall innerhalb von ca. 10-15 Werktagen.

Vereinbaren Sie einen Beratungstermin mit Ihrem Arzt zur Besprechung der Testergebnisse. Wir senden  den Testbericht direkt an Ihren Arzt.

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